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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3C2B
All Species:
11.82
Human Site:
Y289
Identified Species:
28.89
UniProt:
O00750
Number Species:
9
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00750
NP_002637.3
1634
184768
Y289
P
Q
V
P
P
R
T
Y
A
S
R
Y
G
N
R
Chimpanzee
Pan troglodytes
XP_514126
1613
182398
Y289
P
Q
V
P
P
R
T
Y
A
S
R
Y
G
N
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536097
1864
208404
T289
P
P
Q
V
P
P
R
T
Y
A
S
R
Y
A
N
Cat
Felis silvestris
Mouse
Mus musculus
Q61194
1686
190739
T335
S
L
S
G
A
T
V
T
R
S
Q
S
L
I
I
Rat
Rattus norvegicus
O70173
1505
170957
I273
N
S
G
K
I
W
A
I
T
T
A
Y
P
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506878
1462
164902
D261
L
L
R
A
P
G
R
D
W
K
E
G
R
G
I
Chicken
Gallus gallus
XP_417956
2032
228776
Y283
P
Q
V
P
P
R
T
Y
V
S
R
F
G
N
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_696344
1587
179557
E269
R
P
N
G
F
G
Y
E
L
F
Q
V
S
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524028
1876
210456
E468
P
R
N
Q
Q
C
Y
E
S
N
Q
A
A
M
P
Honey Bee
Apis mellifera
XP_396869
1681
191083
S296
P
L
P
P
R
N
S
S
A
W
N
T
I
E
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.2
N.A.
81.7
N.A.
44
31.4
N.A.
77.1
64.9
N.A.
63.2
N.A.
33.2
35.3
N.A.
N.A.
Protein Similarity:
100
98.5
N.A.
83.9
N.A.
62.6
50.9
N.A.
81.6
70.7
N.A.
76.1
N.A.
49
53.1
N.A.
N.A.
P-Site Identity:
100
100
N.A.
13.3
N.A.
6.6
13.3
N.A.
6.6
86.6
N.A.
0
N.A.
6.6
26.6
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
20
N.A.
13.3
26.6
N.A.
6.6
93.3
N.A.
6.6
N.A.
33.3
33.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
10
0
10
0
30
10
10
10
10
10
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
20
0
0
10
0
0
20
10
% E
% Phe:
0
0
0
0
10
0
0
0
0
10
0
10
0
0
0
% F
% Gly:
0
0
10
20
0
20
0
0
0
0
0
10
30
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
10
0
0
0
0
10
10
20
% I
% Lys:
0
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% K
% Leu:
10
30
0
0
0
0
0
0
10
0
0
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
10
0
20
0
0
10
0
0
0
10
10
0
0
30
10
% N
% Pro:
60
20
10
40
50
10
0
0
0
0
0
0
10
0
10
% P
% Gln:
0
30
10
10
10
0
0
0
0
0
30
0
0
0
0
% Q
% Arg:
10
10
10
0
10
30
20
0
10
0
30
10
10
0
50
% R
% Ser:
10
10
10
0
0
0
10
10
10
40
10
10
10
10
0
% S
% Thr:
0
0
0
0
0
10
30
20
10
10
0
10
0
0
0
% T
% Val:
0
0
30
10
0
0
10
0
10
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
10
0
0
10
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
20
30
10
0
0
30
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _